The main difference between autocrine and paracrine is that the autocrine determinants act top top the cells which produce them vice versa, the paracrine components act ~ above the cells that space in near proximity to the cells that create them. 

Autocrine and paracrine are two terms supplied to describe various factors that space a component of the cell signaling mechanisms. Furthermore, the growth factors which stimulate cell division is an example of autocrine factors while cytokines, which reason inflammatory responses, and neurotransmitters released into the synapse space some examples of paracrine factors. 

Key areas Covered 

1. What is Autocrine – Definition, Signaling Molecules, instances 2. What is Paracrine – Definition, Signaling Molecules, instances 3. What space the Similarities in between Autocrine and also Paracrine – synopsis of typical Features 4. What is the Difference in between Autocrine and also Paracrine Comparison of an essential Differences

Key Terms 

Autocrine, Cytokines, Interleukins, Neurotransmitters, Paracrine


What is Autocrine 

Autocrine is the term used to describe a kind of cell signaling molecules that tie to the cell of production. This method that the target cabinet of these signaling molecules is the same cell indigenous which they are produced. Therefore, autocrine signaling helps the cells to send signal to itself. During early development, autocrine signaling ensures the differentiation the cells right into the correct tissue.

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Figure 1: varieties of cabinet Signaling

In addition, autocrine actors such together interleukins pat a an essential role in the breakthrough of inflammation signals and also pain sensation. Interferons space a form of cytokines which deserve to act as autocrine signals in virus-infected cells. They induce programmed cell death of the virus-infected cell.

What is Paracrine 

Paracrine is the term provided to define another type of cell signaling molecules which acts upon the cell that are in near proximity come the cell of production. This method the target cells are adjacent cells and also the diffusion that paracrine molecules occurs through the extracellular matrix. early to the short distance between the target and also the cell of production, paracrine signaling takes a brief time to reach to the target when compared to the endocrine signaling, which diffuses v the bloodstream. Moreover, since the paracrine signal needs to be localized, the paracrine signaling molecules are quickly degraded through enzymes.


Figure 2: Neurotransmitters in the Synaptic Gap

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The most usual example the paracrine signals is the signal transmission v the synaptic gap. Neurotransmitters space the paracrine signaling molecules connected here to transmit nerve impulses from the pre-synaptic neuron to the post-synaptic neuron.

Similarities between Autocrine and Paracrine 

Autocrine and also paracrine room two varieties of cell signaling mechanisms. Also, small protein molecules offer as the signaling molecules in both. 

Difference between Autocrine and Paracrine 


Autocrine means “relating to a cell-produced substance that has an impact on the cell by which it is secreted” if paracrine method “relating to a hormone i m sorry has impact only in the vicinity that the gland secreting it”. This explains the basic difference between autocrine and paracrine.

Types of Signaling Molecules 

Another difference between autocrine and paracrine is the the cytokines and growth components are the main varieties of signaling molecules involved in autocrine signaling while neurotransmitters and hormones are associated in paracrine signaling. 


The target of the autocrine signaling molecules is the cells of production while the target that the paracrine signaling is the cell in the nearby proximity. This is the major difference between autocrine and also paracrine.


Cell differentiation in the early embryo occurs v autocrine signaling while signal transmission with the synaptic space occurs through paracrine signaling. 


Autocrine signaling stimulates the cells of manufacturing while paracrine signaling stimulates the cells in the near proximity. Cytokines and growth components are the autocrine signaling molecules if neurotransmitters space paracrine signaling molecules. The key difference between autocrine and also paracrine is their device of action. 


1. “Types the Signals.” Lumen, Lumen Learning, Available Here

Image Courtesy:

1. “Cell signalling” by Doublethink – Own job-related (Public Domain) via Commons Wikimedia 2. “Figure 09 01 02” by CNX OpenStax – (CC by 4.0) via Commons Wikimedia